1In a Newtonian viscous fluid, the shear stress is directly proportional to which of the following?
Newtonian viscous fluid
Easy
A.Temperature gradient
B.Fluid density only
C.Shear rate (velocity gradient)
D.Pressure gradient only
Correct Answer: Shear rate (velocity gradient)
Explanation:
A Newtonian fluid obeys , meaning shear stress is directly proportional to the shear rate, with viscosity as the constant of proportionality.
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2Which of the following is a common example of a Newtonian fluid?
Newtonian viscous fluid
Easy
A.Toothpaste
B.Ketchup
C.Water
D.Blood
Correct Answer: Water
Explanation:
Water has a constant viscosity independent of shear rate, making it a classic Newtonian fluid. Blood, toothpaste, and ketchup are non-Newtonian.
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3For a Newtonian fluid, viscosity () is best described as:
Newtonian viscous fluid
Easy
A.Constant at a given temperature
B.Decreasing with shear rate
C.Increasing with shear rate
D.Dependent on the applied stress magnitude
Correct Answer: Constant at a given temperature
Explanation:
In a Newtonian fluid, viscosity remains constant regardless of shear rate at a fixed temperature, which is the defining property.
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4A non-viscous (ideal) fluid is characterized by which property?
non viscous fluid
Easy
A.Very high viscosity
B.Zero viscosity
C.Variable viscosity
D.Negative viscosity
Correct Answer: Zero viscosity
Explanation:
An ideal or non-viscous fluid has zero viscosity, meaning there is no internal friction or resistance to flow between fluid layers.
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5In a non-viscous fluid flowing through a pipe, the shear stress between fluid layers is:
non viscous fluid
Easy
A.Maximum at the wall
B.Zero
C.Proportional to velocity
D.Constant everywhere
Correct Answer: Zero
Explanation:
Since a non-viscous fluid has no viscosity, there is no internal friction, so shear stress between adjacent fluid layers is zero.
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6Which property distinguishes a fluid from a solid?
nature of fluids
Easy
A.A fluid has no mass
B.A fluid cannot resist shear stress at rest and flows
C.A fluid cannot be compressed at all
D.A fluid has fixed shape
Correct Answer: A fluid cannot resist shear stress at rest and flows
Explanation:
Fluids continuously deform (flow) under any applied shear stress, whereas solids can resist shear stress and maintain a fixed shape.
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7Which of the following categories includes both liquids and gases?
nature of fluids
Easy
A.Crystals
B.Solids
C.Fluids
D.Elastomers
Correct Answer: Fluids
Explanation:
Fluids is the general term encompassing both liquids and gases, as both can flow and take the shape of their container.
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8The SI unit of dynamic viscosity is:
nature of fluids
Easy
A.Pascal-second ()
B.Pascal ()
C.Newton per meter ()
D.Meter per second ()
Correct Answer: Pascal-second ()
Explanation:
Dynamic viscosity has SI units of (Pascal-second), equivalent to .
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9Blood is generally classified as which type of fluid?
rheological properties of blood
Easy
A.Non-Newtonian fluid
B.Ideal non-viscous fluid
C.Compressible gas
D.Perfectly Newtonian fluid
Correct Answer: Non-Newtonian fluid
Explanation:
Blood is a non-Newtonian fluid because its viscosity changes with shear rate, largely due to the behavior of red blood cells.
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10The hematocrit refers to the volume percentage of which blood component?
rheological properties of blood
Easy
A.Red blood cells
B.Platelets
C.White blood cells
D.Plasma proteins
Correct Answer: Red blood cells
Explanation:
Hematocrit is the percentage of blood volume occupied by red blood cells (erythrocytes), and it strongly influences blood viscosity.
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11As the hematocrit increases, the viscosity of blood generally:
rheological properties of blood
Easy
A.Decreases
B.Increases
C.Remains unchanged
D.Becomes zero
Correct Answer: Increases
Explanation:
A higher concentration of red blood cells increases internal resistance to flow, so blood viscosity rises with increasing hematocrit.
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12At low shear rates in small vessels, red blood cells tend to form stacked aggregates known as:
rheological properties of blood
Easy
A.Emboli
B.Platelets
C.Rouleaux
D.Thrombi
Correct Answer: Rouleaux
Explanation:
At low shear rates, red blood cells aggregate into coin-stack-like structures called rouleaux, which increases apparent blood viscosity.
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13Which layer is the innermost lining of a blood vessel wall?
structure and composition of blood vessels
Easy
A.Tunica media
B.Tunica externa
C.Tunica intima
D.Tunica adventitia
Correct Answer: Tunica intima
Explanation:
The tunica intima is the innermost layer, lined by endothelial cells that are in direct contact with the flowing blood.
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14The middle layer of an artery, rich in smooth muscle and elastic fibers, is called the:
structure and composition of blood vessels
Easy
A.Tunica intima
B.Tunica media
C.Tunica adventitia
D.Endothelium
Correct Answer: Tunica media
Explanation:
The tunica media is the middle layer composed mainly of smooth muscle and elastic tissue, controlling vessel diameter and elasticity.
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15Which structural protein provides elasticity to arterial walls, allowing them to stretch and recoil?
structure and composition of blood vessels
Easy
A.Fibrinogen
B.Keratin
C.Myosin
D.Elastin
Correct Answer: Elastin
Explanation:
Elastin fibers allow arterial walls to stretch during systole and recoil during diastole, giving them their elastic behavior.
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16Vascular remodeling refers to which of the following?
remodeling of blood vessels
Easy
A.The measurement of blood pressure
B.The clotting of blood inside a vessel
C.Complete removal of all blood vessels
D.Structural changes in vessel walls in response to stimuli
Correct Answer: Structural changes in vessel walls in response to stimuli
Explanation:
Vascular remodeling is the adaptive structural change in the geometry and composition of blood vessel walls in response to mechanical or biochemical stimuli.
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17Chronic high blood pressure (hypertension) typically causes arterial walls to:
remodeling of blood vessels
Easy
A.Disappear
B.Thicken
C.Become non-viscous
D.Lose all smooth muscle
Correct Answer: Thicken
Explanation:
Sustained high pressure stimulates wall remodeling, commonly thickening the arterial wall (hypertrophy) to withstand the increased stress.
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18Arterioles are primarily responsible for controlling which of the following?
mechanical properties of arterioles
Easy
A.Vascular resistance and blood flow distribution
B.Gas exchange with tissues
C.Return of blood to the heart
D.Storage of the largest blood volume
Correct Answer: Vascular resistance and blood flow distribution
Explanation:
Arterioles are the main resistance vessels; by adjusting their diameter, they regulate peripheral resistance and distribute blood flow to tissues.
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19Which vessels are the primary site of exchange of oxygen, nutrients, and waste with tissues?
capillary vessels and veins
Easy
A.Arterioles
B.Veins
C.Capillaries
D.Arteries
Correct Answer: Capillaries
Explanation:
Capillaries have very thin walls (single endothelial layer), making them the main site for exchange of gases, nutrients, and wastes between blood and tissues.
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20Veins commonly contain which structure to prevent the backflow of blood?
capillary vessels and veins
Easy
A.Nephrons
B.Valves
C.Alveoli
D.Villi
Correct Answer: Valves
Explanation:
Veins contain one-way valves that prevent backflow and help return blood toward the heart, especially against gravity in the limbs.
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21For a Newtonian fluid, the shear stress is related to the shear rate by . If the shear rate doubles while temperature is held constant, how does the shear stress change?
Newtonian viscous fluid
Medium
A.It remains unchanged
B.It increases four-fold
C.It doubles
D.It halves
Correct Answer: It doubles
Explanation:
In a Newtonian fluid viscosity is constant, so shear stress is directly proportional to shear rate. Doubling doubles .
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22Water flows through a pipe and behaves as a Newtonian fluid. Which plot correctly describes its shear stress versus shear rate relationship?
Newtonian viscous fluid
Medium
A.A straight line passing through the origin
B.A curve concave upward from the origin
C.A straight line with a positive intercept on the stress axis
D.A curve concave downward from the origin
Correct Answer: A straight line passing through the origin
Explanation:
Newtonian fluids show a linear stress–strain-rate relation with zero yield stress, giving a straight line through the origin whose slope equals viscosity.
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23An ideal (non-viscous) fluid is assumed in many introductory analyses. Which consequence follows directly from neglecting viscosity?
non viscous fluid
Medium
A.The fluid becomes incompressible automatically
B.The fluid density increases with velocity
C.Pressure becomes independent of depth
D.No shear stress can develop within the fluid
Correct Answer: No shear stress can develop within the fluid
Explanation:
Viscosity is the property responsible for internal shear stresses. A non-viscous (inviscid) fluid, by definition, cannot sustain shear stress between layers.
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24Bernoulli's equation in its classic form is most directly applicable to which type of flow?
non viscous fluid
Medium
A.Compressible flow with large friction losses
B.Unsteady flow with significant heat transfer
C.Steady, incompressible, non-viscous flow along a streamline
D.Turbulent viscous flow in a rough pipe
Correct Answer: Steady, incompressible, non-viscous flow along a streamline
Explanation:
Bernoulli's equation assumes energy conservation without viscous dissipation, so it applies to steady, incompressible, inviscid flow along a streamline.
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25Blood is best classified rheologically as which type of fluid at low shear rates?
rheological properties of blood
Medium
A.Shear-thickening (dilatant)
B.Ideal inviscid fluid
C.Non-Newtonian, shear-thinning
D.Newtonian with constant viscosity
Correct Answer: Non-Newtonian, shear-thinning
Explanation:
Blood viscosity decreases as shear rate increases because red cells disaggregate and align, making it a shear-thinning (pseudoplastic) non-Newtonian fluid.
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26The Fåhraeus–Lindqvist effect describes which observed behavior of blood?
rheological properties of blood
Medium
A.Red cells migrate toward the vessel wall in small tubes
B.Apparent viscosity rises sharply in large arteries
C.Plasma viscosity increases with hematocrit only
D.Apparent viscosity decreases as tube diameter decreases below about 300
Correct Answer: Apparent viscosity decreases as tube diameter decreases below about 300
Explanation:
In small vessels, red cells move to the axial core leaving a cell-poor layer near the wall, reducing apparent viscosity as diameter falls (Fåhraeus–Lindqvist effect).
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27If a patient's hematocrit rises significantly due to dehydration, the most likely effect on whole-blood viscosity is that it will:
rheological properties of blood
Medium
A.Remain constant
B.Increase
C.Decrease
D.Drop to that of plasma
Correct Answer: Increase
Explanation:
Hematocrit is the volume fraction of red cells. A higher cell concentration raises internal resistance to flow, increasing blood viscosity.
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28The Casson model is often used for blood because it accounts for which feature not captured by a simple Newtonian model?
rheological properties of blood
Medium
A.A viscosity that increases with shear rate
B.Complete absence of internal friction
C.A density that varies with pressure
D.A yield stress that must be exceeded before flow begins
Correct Answer: A yield stress that must be exceeded before flow begins
Explanation:
The Casson model incorporates a yield stress arising from red-cell aggregation; below it blood behaves like a solid, above it flow occurs.
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29The tunica media of a large artery is dominated by which components, giving the vessel its recoil and strength?
structure and composition of blood vessels
Medium
A.Smooth muscle and elastic fibers
B.Loose connective tissue and nerves
C.Endothelial cells only
D.Collagen fibers exclusively
Correct Answer: Smooth muscle and elastic fibers
Explanation:
The tunica media contains circumferentially arranged smooth muscle and elastin, providing elastic recoil and vasomotor control in arteries.
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30Which layer of a blood vessel is in direct contact with flowing blood and helps regulate permeability and thrombosis?
structure and composition of blood vessels
Medium
A.Tunica intima (endothelium)
B.External elastic lamina
C.Tunica media
D.Tunica adventitia
Correct Answer: Tunica intima (endothelium)
Explanation:
The tunica intima's endothelial lining directly contacts blood, controlling permeability, vascular tone signaling, and anti-thrombotic function.
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31Compared with an artery of similar diameter, a vein typically has:
structure and composition of blood vessels
Medium
A.More elastic tissue than any artery
B.A thicker tunica media and smaller lumen
C.A thinner tunica media and larger lumen
D.No tunica intima at all
Correct Answer: A thinner tunica media and larger lumen
Explanation:
Veins operate at low pressure, so they have thinner muscular walls and relatively larger lumens than comparable arteries, and many contain valves.
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32Chronic hypertension often leads to vascular remodeling characterized by:
remodeling of blood vessels
Medium
A.Complete loss of smooth muscle
B.Thickening of the arterial wall and increased wall-to-lumen ratio
C.Thinning of the media and dilation of the lumen
D.Conversion of arteries into capillaries
Correct Answer: Thickening of the arterial wall and increased wall-to-lumen ratio
Explanation:
Sustained high pressure increases wall stress, prompting smooth-muscle hypertrophy and matrix deposition that thicken the wall and raise the wall-to-lumen ratio.
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33According to the principle underlying vascular remodeling, a chronic increase in blood flow through a vessel tends to cause the vessel to:
remodeling of blood vessels
Medium
A.Increase its lumen diameter to normalize wall shear stress
B.Decrease its diameter to raise shear stress
C.Become permanently rigid
D.Lose its endothelial layer
Correct Answer: Increase its lumen diameter to normalize wall shear stress
Explanation:
Vessels remodel to keep wall shear stress near a set point; sustained high flow raises shear stress, triggering outward remodeling that enlarges the lumen.
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34A fluid is defined mechanically as a substance that:
nature of fluids
Medium
A.Continuously deforms under any applied shear stress
B.Cannot transmit pressure
C.Resists all shear stress indefinitely
D.Has a fixed shape independent of its container
Correct Answer: Continuously deforms under any applied shear stress
Explanation:
Unlike solids, fluids cannot sustain shear at rest; they deform continuously as long as shear stress is applied, distinguishing liquids and gases from solids.
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35Which pair of properties primarily distinguishes a liquid from a gas within the general category of fluids?
nature of fluids
Medium
A.Transparency and temperature
B.Compressibility and definite volume
C.Ability to flow and viscosity only
D.Density and color
Correct Answer: Compressibility and definite volume
Explanation:
Liquids are nearly incompressible with a definite volume, whereas gases are highly compressible and expand to fill their container, even though both flow.
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36For an organism swimming at very low Reynolds number (e.g., a bacterium), propulsion is dominated by:
propulsion in fluid medium
Medium
A.Viscous forces, so reciprocal motion produces no net movement
B.Gravitational forces overcoming drag
C.Inertial forces, allowing coasting between strokes
D.Surface tension pulling it forward
Correct Answer: Viscous forces, so reciprocal motion produces no net movement
Explanation:
At low Reynolds number viscosity dominates inertia; by the scallop theorem, time-reversible (reciprocal) motion yields no net displacement, so microswimmers use non-reciprocal strokes.
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37A fish that increases its swimming speed in water experiences drag that, for turbulent high-Reynolds-number flow, scales approximately as:
propulsion in fluid medium
Medium
A.Directly with its velocity
B.The inverse of its velocity
C.The square of its velocity
D.Independent of its velocity
Correct Answer: The square of its velocity
Explanation:
At high Reynolds number, form (pressure) drag dominates and follows , so doubling speed roughly quadruples drag force.
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38Arterioles are considered the primary resistance vessels because they:
mechanical properties of arterioles
Medium
A.Lack any smooth muscle
B.Have a thick smooth-muscle layer that adjusts diameter to control resistance
C.Possess the largest lumen of all vessels
D.Contain valves that block backflow
Correct Answer: Have a thick smooth-muscle layer that adjusts diameter to control resistance
Explanation:
Arterioles have a relatively thick smooth-muscle wall; vasoconstriction and vasodilation change radius sharply, and since resistance , they dominate systemic resistance.
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39Using Poiseuille's law, if an arteriole constricts so its radius decreases by 20% (to ) with all else constant, the resistance to flow increases by a factor of about:
mechanical properties of arterioles
Medium
A.
B.
C.
D.
Correct Answer:
Explanation:
Resistance . New resistance factor , showing how small radius changes greatly affect resistance.
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40Despite having the smallest individual radius, capillaries offer relatively low resistance to overall flow mainly because:
capillary vessels and veins
Medium
A.They carry blood at the highest pressure in the system
B.Each capillary has a thick muscular wall
C.Blood becomes non-viscous in capillaries
D.Their enormous total cross-sectional area from parallel arrangement lowers velocity and combined resistance
Correct Answer: Their enormous total cross-sectional area from parallel arrangement lowers velocity and combined resistance
Explanation:
Billions of capillaries in parallel give a huge combined cross-sectional area, greatly reducing flow velocity and the network's overall resistance despite small individual radii.
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41For a Newtonian fluid in steady laminar flow between two parallel plates separated by distance , the top plate moves at velocity while the bottom is stationary. If the dynamic viscosity is , what is the shear stress acting on the fluid, and how does it vary across the gap?
Newtonian viscous fluid
Hard
A., varying linearly from zero at the bottom to maximum at top
B., constant across the entire gap
C., constant across the entire gap
D., maximum at the center of the gap
Correct Answer: , constant across the entire gap
Explanation:
In Couette flow the velocity profile is linear, so the velocity gradient is uniform. Since for a Newtonian fluid, the shear stress is constant everywhere in the gap.
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42An idealized non-viscous (inviscid) fluid flows steadily through a horizontal converging nozzle. Which statement correctly describes the consequences of the zero-viscosity assumption in this flow?
non viscous fluid
Hard
A.The no-slip condition holds at the wall, producing a parabolic velocity profile
B.There is no wall shear stress and no boundary layer, so Bernoulli's equation applies along a streamline
C.Wall shear stress is finite but the boundary layer thickness is zero
D.Viscous dissipation converts kinetic energy to heat, reducing pressure recovery
Correct Answer: There is no wall shear stress and no boundary layer, so Bernoulli's equation applies along a streamline
Explanation:
An inviscid fluid has , eliminating shear stress, boundary layers, viscous dissipation, and the no-slip condition. Energy is conserved along a streamline, allowing direct application of Bernoulli's equation.
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43Blood exhibits shear-thinning behavior well described by the Casson model . Physiologically, why does apparent viscosity decrease as shear rate increases in large arteries?
rheological properties of blood
Hard
A.Plasma proteins denature and reduce plasma viscosity at high shear
B.Hematocrit rises near the wall, thickening the marginal plasma layer
C.Red cell membranes stiffen, decreasing the effective cell volume fraction
D.Erythrocytes deform and align with flow while rouleaux disaggregate, lowering internal friction
Correct Answer: Erythrocytes deform and align with flow while rouleaux disaggregate, lowering internal friction
Explanation:
At low shear rates RBCs form rouleaux aggregates that raise viscosity. As shear increases, these aggregates break up and cells deform and align with streamlines, reducing apparent viscosity — the hallmark of shear-thinning.
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44The Fåhræus–Lindqvist effect describes how apparent blood viscosity changes in small tubes. For vessels with diameters roughly between 10 and 300 , what happens and why?
rheological properties of blood
Hard
A.Apparent viscosity increases because RBCs jam against the wall and raise local hematocrit
B.Apparent viscosity decreases because RBCs migrate to the axis, leaving a low-viscosity cell-free plasma layer near the wall
C.Apparent viscosity decreases because plasma viscosity itself drops in narrow tubes
D.Apparent viscosity is unchanged because blood behaves as a continuum at all scales
Correct Answer: Apparent viscosity decreases because RBCs migrate to the axis, leaving a low-viscosity cell-free plasma layer near the wall
Explanation:
In small tubes red cells migrate toward the centerline, forming a cell-free plasma layer at the wall that lubricates flow. This lowers the apparent viscosity as diameter decreases, until diameters approach a single cell size where viscosity rises again (inverse Fåhræus–Lindqvist).
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45Comparing the tunica media of a large elastic artery (e.g., aorta) with that of a muscular artery, which structural difference explains their distinct mechanical roles?
structure and composition of blood vessels
Hard
A.The muscular artery has more elastin, making it stiffer than the elastic artery
B.The elastic artery has more elastic lamellae for passive recoil, while the muscular artery has more smooth muscle for active diameter control
C.The elastic artery lacks smooth muscle entirely, relying only on collagen
D.Both have identical media composition but differ only in endothelial thickness
Correct Answer: The elastic artery has more elastic lamellae for passive recoil, while the muscular artery has more smooth muscle for active diameter control
Explanation:
Elastic arteries near the heart contain concentric elastic lamellae that store energy during systole and recoil during diastole (Windkessel effect). Muscular arteries have proportionally more smooth muscle, enabling active regulation of vessel diameter and flow distribution.
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46Arterioles are the primary site of vascular resistance. Using Poiseuille's law , if an arteriole constricts so its radius decreases by 20%, by approximately what factor does its resistance increase (assuming and constant)?
mechanical properties of arterioles, capillary vessels and veins
Hard
A.
B.
C.
D.
Correct Answer:
Explanation:
Resistance scales as . A 20% reduction gives , so the factor is . This fourth-power sensitivity is why arterioles are such powerful resistance regulators.
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47According to the law of Laplace for a thin-walled cylinder, wall tension . In sustained hypertension, how does an artery typically remodel to normalize wall stress ?
B.It decreases both radius and wall thickness proportionally, preserving the ratio
C.It increases radius while thinning the wall to accommodate flow
D.It leaves geometry unchanged because stress is regulated purely by endothelial signaling
Correct Answer: It increases wall thickness (hypertrophic/eutrophic inward remodeling) to reduce circumferential stress
Explanation:
Elevated pressure raises wall stress . To restore homeostatic stress, vessels thicken the wall (increasing ) and often reduce lumen radius, lowering the numerator and raising the denominator. This inward/hypertrophic remodeling normalizes stress.
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48A microorganism swimming at very low Reynolds number () cannot use reciprocal motion for net propulsion. This constraint is best summarized by which principle?
propulsion in fluid medium
Hard
A.The scallop theorem: time-reversible (reciprocal) deformations produce zero net displacement in Stokes flow
B.D'Alembert's paradox: drag vanishes so no propulsion is possible
C.The continuity equation: mass conservation forbids net motion at low
D.Bernoulli's principle: pressure differences from reciprocal motion cancel out
Correct Answer: The scallop theorem: time-reversible (reciprocal) deformations produce zero net displacement in Stokes flow
Explanation:
At low inertia is negligible and Stokes flow is time-reversible. Pureley's scallop theorem states any reciprocal (back-and-forth) stroke yields no net motion, so microswimmers must use non-reciprocal motions like rotating helical flagella.
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49For a fluid element in a flowing continuum, which statement correctly distinguishes a fluid from a solid in terms of mechanical response to shear?
nature of fluids
Hard
A.Both fluid and solid support shear stress statically without deformation
B.A fluid resists shear with a fixed strain, whereas a solid flows indefinitely
C.A fluid deforms continuously (flows) under any nonzero shear stress, whereas a solid attains a finite static deformation
D.A fluid supports shear only above a yield stress that all solids also possess
Correct Answer: A fluid deforms continuously (flows) under any nonzero shear stress, whereas a solid attains a finite static deformation
Explanation:
The defining property of a fluid is that it cannot sustain shear statically: any applied shear stress causes continuous deformation (flow). An elastic solid responds to shear with a finite, recoverable strain and reaches equilibrium.
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50Capillaries have extremely thin walls yet do not rupture despite substantial transmural pressure. Which combination of factors, via Laplace's law , best explains this?
mechanical properties of arterioles, capillary vessels and veins
Hard
A.Their very small radius keeps wall tension low, so a thin single-cell wall suffices
B.Their large radius is offset by high collagen content in the wall
C.Their high flow velocity reduces the effective transmural pressure
D.Their thick smooth muscle layer bears the entire wall tension
Correct Answer: Their very small radius keeps wall tension low, so a thin single-cell wall suffices
Explanation:
By Laplace's law, wall tension is proportional to radius. Capillaries have radii of only a few micrometers, so even at meaningful transmural pressures the tension is minute — a thin endothelial wall with basement membrane can withstand it without smooth muscle.
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51Veins operate at low pressure and act as capacitance vessels. Their pressure–volume (compliance) curve is highly nonlinear. What best describes venous behavior at low versus high filling?
mechanical properties of arterioles, capillary vessels and veins
Hard
A.At low volume they change from collapsed elliptical to circular cross-section with little pressure rise, then stiffen sharply once circular
B.They collapse fully at high volume due to smooth muscle contraction
C.Compliance is constant across all filling states, giving a linear P–V line
D.They stiffen at low volume and become highly compliant only at high filling
Correct Answer: At low volume they change from collapsed elliptical to circular cross-section with little pressure rise, then stiffen sharply once circular
Explanation:
Empty veins have a collapsed, elliptical cross-section. Initial filling reshapes them toward circular with minimal pressure change (high compliance). Once circular, further volume stretches the wall, so pressure rises steeply (low compliance) — a sharply nonlinear P–V curve.
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52For fully developed laminar Newtonian flow in a rigid circular tube of radius , the velocity profile is parabolic. What is the ratio of the maximum (centerline) velocity to the mean velocity?
Newtonian viscous fluid
Hard
A.
B.
C.
D.
Correct Answer:
Explanation:
For Hagen–Poiseuille flow, . Integrating over the cross-section gives , so .
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53The Casson model gives blood a yield stress . What is the practical physiological consequence of this yield stress in the microcirculation during very low-flow states?
rheological properties of blood
Hard
A.The yield stress guarantees turbulent flow at all shear rates
B.Blood viscosity becomes zero, so flow accelerates uncontrollably
C.Yield stress only affects plasma, not whole blood, so flow is unaffected
D.Blood can stop flowing (plug/stasis) in small vessels when shear stress falls below , risking sludging
Correct Answer: Blood can stop flowing (plug/stasis) in small vessels when shear stress falls below , risking sludging
Explanation:
A yield stress means blood behaves like a solid until . In low-flow, low-shear conditions, stress can drop below the yield value, causing RBC aggregation, sludging, and potential stasis in the microcirculation.
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54The three tunicae of a vessel bear load differently. In the physiological pressure range of a large artery, which component dominates load-bearing, and what happens at higher pressures?
structure and composition of blood vessels
Hard
A.Elastin bears load at physiological pressure; at higher pressure stiffer collagen fibers are recruited, causing nonlinear stiffening
B.Smooth muscle bears all passive load regardless of pressure
C.The endothelium bears the circumferential load through tight junctions
D.Collagen bears load at low pressure while elastin is recruited only at high pressure
Correct Answer: Elastin bears load at physiological pressure; at higher pressure stiffer collagen fibers are recruited, causing nonlinear stiffening
Explanation:
At normal pressures, compliant elastin fibers carry the load. As pressure rises and the wall stretches, initially crimped, much stiffer collagen fibers straighten and engage, producing the characteristic J-shaped (strain-stiffening) stress–strain curve of arteries.
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55Chronic increases in blood flow (elevated wall shear stress sensed by the endothelium) typically drive outward remodeling. Which mediator and geometric outcome are correctly paired?
remodeling of blood vessels
Hard
A.Reduced nitric oxide causes lumen enlargement to lower flow velocity
B.Endothelin-1 release promotes lumen enlargement to increase shear stress
C.Increased collagen deposition narrows the lumen to raise shear stress
Wall shear stress . Sustained high flow raises , and the endothelium responds by releasing NO (a vasodilator/remodeling signal) that enlarges the lumen. Increasing lowers back toward its homeostatic setpoint.
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56The Reynolds number determines the propulsion regime. A bacterium (, ) and a fish (, ) differ enormously in . What is the key propulsive implication?
propulsion in fluid medium
Hard
A.Reynolds number is identical since both move in water, so propulsion strategies match
B.The bacterium lives in a viscous-dominated regime and must exploit drag/non-reciprocal motion, while the fish exploits inertial thrust
C.Both use inertial thrust because water is the same medium
D.The fish is viscosity-dominated because it is larger
Correct Answer: The bacterium lives in a viscous-dominated regime and must exploit drag/non-reciprocal motion, while the fish exploits inertial thrust
Explanation:
The bacterium's (viscous-dominated Stokes flow) forces non-reciprocal, drag-based propulsion. The fish's is inertia-dominated, allowing it to generate thrust by accelerating fluid momentum with fins/body undulation.
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57Consider a fluid whose apparent viscosity increases with shear rate. How is this behavior classified, and which everyday example fits?
nature of fluids
Hard
A.Shear-thinning (pseudoplastic); ketchup
B.Bingham plastic; toothpaste
C.Shear-thickening (dilatant); a cornstarch–water suspension
D.Newtonian; pure water
Correct Answer: Shear-thickening (dilatant); a cornstarch–water suspension
Explanation:
A fluid whose apparent viscosity rises with increasing shear rate is dilatant (shear-thickening). Concentrated cornstarch suspensions are the classic example, becoming nearly solid under rapid deformation.
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58Two Newtonian fluids A and B have the same dynamic viscosity , but fluid A is twice as dense as fluid B. In identical pipe flow geometry driven at the same mean velocity, how do their Reynolds numbers and kinematic viscosities compare?
Newtonian viscous fluid
Hard
A.Fluid A has twice the kinematic viscosity and half the Reynolds number of fluid B
B.Fluid A has half the kinematic viscosity and the same Reynolds number as fluid B
C.Fluid A has half the kinematic viscosity and twice the Reynolds number of fluid B
D.Both have identical kinematic viscosity and Reynolds number
Correct Answer: Fluid A has half the kinematic viscosity and twice the Reynolds number of fluid B
Explanation:
Kinematic viscosity ; doubling halves . Since , halving (or doubling ) doubles at fixed and .
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59The endothelium (part of the tunica intima) is not merely a passive lining. Which mechanotransduction role best explains its central importance in vascular biology?
structure and composition of blood vessels
Hard
A.It stores elastic energy during systole for diastolic recoil
B.It senses wall shear stress and secretes vasoactive mediators (NO, endothelin) that regulate tone and remodeling
C.It generates the pulsatile pressure wave that propels blood
D.It provides the main circumferential tensile strength of the vessel wall
Correct Answer: It senses wall shear stress and secretes vasoactive mediators (NO, endothelin) that regulate tone and remodeling
Explanation:
Endothelial cells detect hemodynamic forces, especially wall shear stress, and translate them into biochemical signals. By releasing vasodilators (NO) and vasoconstrictors (endothelin-1), they control vascular tone, permeability, and long-term remodeling.
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60The Windkessel model treats large arteries as a compliant reservoir. During diastole, blood continues to flow forward even though the heart is not ejecting. What mechanism accounts for this, and which parameter governs the diastolic pressure decay?
mechanical properties of arterioles, capillary vessels and veins
Hard
A.Capillary osmotic pressure drives flow, governed by plasma protein concentration
B.Inertia of blood alone drives forward flow, governed by fluid density
C.Venous suction pulls blood forward, governed by venous compliance
D.Elastic recoil of arterial walls drives forward flow; the decay time constant is (resistance compliance)
Correct Answer: Elastic recoil of arterial walls drives forward flow; the decay time constant is (resistance compliance)
Explanation:
Arteries stretched during systole store elastic energy; in diastole they recoil, maintaining forward flow. The Windkessel model predicts an exponential pressure decay , where is peripheral resistance and is arterial compliance.
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